Siyu Fu

Papers

Total Citations

204

H-Index

About

Dr. Siyu Fu is a pioneering researcher in ocular surface proteomics, best known for groundbreaking work in tear film diagnostics. Her most influential study, "SELDI-TOF-MS ProteinChip Array Profiling of Tears from Patients with Dry Eye" (2005, 204 citations), established a novel methodological framework for analyzing tear protein and peptide profiles in dry eye disease. This work demonstrated that surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) could effectively identify distinct protein expression patterns differentiating dry eye patients from healthy controls. By moving beyond traditional electrophoretic protein profiling, Fu's research opened new avenues for non-invasive biomarker discovery in ophthalmology. Her contributions have been instrumental in advancing our understanding of the molecular mechanisms underlying ocular surface inflammation and dysfunction. The high citation count of her seminal paper reflects its enduring impact on both clinical diagnostics and basic science research in dry eye disease. Fu's work continues to influence subsequent generations of researchers exploring proteomic approaches to ocular surface disorders, cementing her legacy as a key figure in the application of advanced mass spectrometry techniques to ophthalmology.