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About

S. Cusack is a leading structural biologist whose work has fundamentally advanced our understanding of viral pathogens and the tools used to study them. His primary research areas encompass structural genomics, macromolecular crystallography, and the molecular biology of viruses, with a particular focus on the Epstein–Barr virus (EBV) and influenza virus. A major contribution is his pioneering role in establishing the SPINE standard sample holder for cryocooled macromolecular crystals, a critical innovation that enabled the automation of sample mounting for high-throughput crystallography. This widely adopted standard, detailed in a paper with 111 citations, has streamlined structural biology workflows globally. Cusack also led a landmark structural genomics project on EBV, systematically determining the structures of its proteins to illuminate mechanisms of infection and oncogenesis. This work, which involved re-annotating the EBV genome and expressing 23 open reading frames, has garnered 44 citations and provided a vital resource for antiviral drug design. Through these achievements, Cusack has not only solved key biological structures but also engineered the very tools that accelerate discovery in his field.