Pedro Ivonnet
Papers
1
Total Citations
38
H-Index
1
About
Pedro Ivonnet is a pulmonary researcher whose work centers on airway epithelial biology, mucociliary clearance, and the molecular mechanisms underlying smoking-related lung disease. His most cited study, "Roflumilast partially reverses smoke-induced mucociliary dysfunction" (2015, 38 citations), demonstrates a key contribution: showing that the PDE4 inhibitor roflumilast can restore CFTR function and improve mucociliary clearance in smoke-exposed airways by elevating intracellular cAMP. This finding has implications for treating chronic obstructive pulmonary disease (COPD) and cystic fibrosis, linking basic phosphodiesterase biology to a potential therapeutic strategy. Ivonnet’s research clarifies how tobacco smoke disrupts airway defenses and identifies PDE4 inhibition as a means to counteract that damage. His work is highly relevant for researchers studying ion transport, mucus dynamics, and drug targets for obstructive lung diseases. With a focused publication record, Ivonnet has established himself as a specialist in the intersection of CFTR regulation, PDE signaling, and environmental lung injury, offering mechanistic insights that bridge cell biology and clinical application.
Research Focus
Key Achievements
Top Papers
- 1Roflumilast partially reverses smoke-induced mucociliary dysfunction38 citations · 2015