Hisashi Naitow
Papers
1
Total Citations
29
H-Index
1
About
Hisashi Naitow has made pivotal contributions to structural genomics, particularly through his work on the thermophilic bacterium *Thermus thermophilus* HB8. His research focuses on high-throughput protein crystallization and structural biology, enabling the systematic determination of protein structures from this model organism. Naitow’s most cited work, a 2008 study with 29 citations, introduced a comprehensive crystallization screening test that integrated three robotic systems—the HTS-80 for sitting-drop vapor diffusion, the Crystal Finder for hanging-drop vapor diffusion, and the TERA for modified microbatch methods. This automated approach dramatically improved the efficiency of crystallizing numerous proteins, overcoming a major bottleneck in the whole-cell project. By streamlining the crystallization pipeline, Naitow’s contributions accelerated the structural characterization of *T. thermophilus* proteins, providing insights into thermostability and protein function. His work exemplifies the power of automation in structural genomics, impacting fields from enzymology to drug design. Naitow’s achievements underscore his role in advancing high-throughput methods that continue to support large-scale structural biology initiatives.
Research Focus
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Top Papers
- 1