Clarence Lew

Papers

Total Citations

116

H-Index

About

Clarence Lew is a leading figure in biopharmaceutical analytics, with his research centered on the high-throughput characterization of therapeutic antibodies. His most impactful work addresses a critical bottleneck in the industry: the need for rapid, reproducible, and fully automated N-glycan analysis. Lew’s landmark 2014 paper, “Rapid Magnetic Bead Based Sample Preparation for Automated and High Throughput N-Glycan Analysis of Therapeutic Antibodies,” has garnered 116 citations, reflecting its profound influence. In this study, he pioneered a method that replaces labor-intensive, manual sample preparation with an automated magnetic bead-based workflow, enabling the high-throughput profiling and sequencing of N-glycosylation. This innovation directly meets the rigorous reproducibility standards demanded by both the biopharmaceutical industry and national regulatory agencies. By streamlining a traditionally complex process, Lew’s work has significantly accelerated the development and quality control of monoclonal antibody therapeutics. His contributions are essential for any researcher or student seeking to understand modern glycoanalytical strategies, demonstrating how automation can overcome the limitations of conventional capillary electrophoresis-based methods to deliver robust, scalable solutions for drug development.