Alison Bienemann

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About

Alison Bienemann’s research focuses on overcoming one of the most formidable challenges in neuro-oncology: the blood-brain barrier. Her work centers on developing innovative drug delivery systems to treat glioblastoma, the most aggressive form of brain cancer. Bienemann is best known for her pioneering contributions to convection-enhanced delivery (CED), a technique that bypasses the BBB to infuse therapeutics directly into brain tissue. Her highly cited 2014 study introduced a novel implantable catheter system with a transcutaneous port for intermittent CED of carboplatin in recurrent glioblastoma patients. This work demonstrated the feasibility of repeated, controlled infusions directly into tumors, addressing the critical failure of systemic chemotherapy to penetrate the brain. With 73 citations, this paper has become a foundational reference for researchers seeking to translate CED from preclinical models into clinical practice. Bienemann’s contributions are vital for advancing targeted, localized treatments that could improve prognosis for patients with otherwise intractable brain cancers, making her a key figure in the fight against glioblastoma.